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23-06-2025 | Seminar

Anastasiia Horlova: A study of the genetic circuits of intestinal stem cell differentiation using in vivo CRISPR perturbation and single-cell RNA-seq.<br /> Emma Kneuss: Exploring the consequences of altered X-Inactivation during embryonic development

<p><p><strong>Abstract</strong><br>Anastasiia Horlova: <span style="background-color:rgb(255,255,255);color:rgb(0,0,0);">Understanding how genetic networks enable animals to develop and maintain complex tissues is a central goal of biological research. We investigate how intestinal stem cells (ISCs) contribute to the generations of differentiated cell types in the <i>Drosophila</i> midgut. We use single-cell transcriptomic data from in vivo CRISPR gene knockdown experiments that specifically affect <i>Drosophila melanogaster</i> ISCs, in their native context within healthy adult animals. Our goal is to systematically examine the consequences of single gene perturbations on cellular behaviour.</span></p><p>Emma Kneuss: <span style="color:rgb(0,0,0);">X-chromosome inactivation (XCI) is a crucial developmental process in female mammals that balances gene dosage between XX females and XY males by silencing one X chromosome. Historically, XCI has been viewed as a tightly controlled event restricted to early embryogenesis. However, emerging evidence suggests that modulation of the key silencing factor, Xist RNA, can disrupt this balance. In this talk, I will present my work exploring how aberrant levels, either depletion or excess, of Xist RNA or its partners influence embryonic development, shedding light on the broader consequences of altered XCI dynamics.</span></p><p><strong>About the speaker</strong><br>[Biographical information about the speaker].</p><p><strong>Meet the speaker</strong><br>To meet with the speaker informally after the talks,<strong>sign up here [add link]</strong>. We especially encourage <strong>predocs and postdocs</strong> to take advantage of this opportunity.</p><p><strong>Attachments</strong><br>[Link to a file (for example a pdf of the seminar’s programme) - the file can be uploaded on the intranet]</p><p><strong>Connection details</strong><br><strong>Zoom*</strong>: [link] (Meeting ID: [XXXXXXXXX], Password: [XXXXXXX])</p><p>Please note that the talk will <strong>yes/not</strong> be recorded.<br><i>*For the FAQ section, as a zoom participant, please use either the chat function (the host will read out your question) <u>or</u> the “raise your hand” function and turn on your microphone.</i></p></p>

13-11-2025 | Course

Chemicals in a biological context: metabolites, drugs, and beyond

<p><p dir="ltr"><span>Small molecules (or chemicals) play a crucial role in biological systems, acting as precursors to macromolecules, cells, and tissues. Beyond this,&nbsp;they are involved in cell signalling, regulation, energy consumption and production, and can be used therapeutically to treat diseases. Metabolites, a subset of small molecules, are the chemical intermediates and/or end products of metabolic processes.</span></p><p dir="ltr"><span>To understand the role of chemicals in a biological context, we can study how they bind to and impact the function of their macromolecular targets, such as DNA, RNA, and protein. We can also assess their broader functional impact on cells, tissues, blood, and other biofluids.</span></p><p dir="ltr"><span>This six-hour virtual workshop offers hands-on experience with EMBL-EBI tools and resources to explore the biological effects of small molecules. Using a case study, we will guide participants through workflows to investigate drug interactions with a protein target, as well as assess the downstream effects within a biological system.&nbsp;</span></p><p><span>We will use&nbsp;</span><a href="<a href="https://www.ebi.ac.uk/chembl/"><span>ChEMBL</span></a><span&gt">https://www.ebi.ac.uk/chembl/"><span>ChEMBL</span></a><span&gt</a>; to identify small molecule drugs and experimental data on their impact on targets,&nbsp;</span><a href="<a href="https://www.ebi.ac.uk/pdbe/"><span>PDBe</span></a><span&gt">https://www.ebi.ac.uk/pdbe/"><span>PDBe</span></a><span&gt</a>; to evaluate target binding details, and&nbsp;</span><a href="<a href="https://www.ebi.ac.uk/metabolights/"><span>MetaboLights</span></a><span&gt">https://www.ebi.ac.uk/metabolights/"><span>MetaboLights</span></a><span…</a>; to investigate the small molecule’s impact on biological systems.</span><br><br><br><strong>Virtual course</strong></p><p dir="ltr"><span>This course will take place on Zoom. Trainers will be available to assist during practical sessions, answer questions, and provide further explanations during the Zoom.</span></p><p dir="ltr"><span>To join the course you will need to create an </span><a href="<a href="https://www.ebi.ac.uk/training/user/login"><span>EMBL-EBI">https://www.ebi.ac.uk/training/user/login"><span>EMBL-EBI</a> Training website account</span></a><span>.</span><br>&nbsp;</p></p>

25-08-2026 | Conference

Transcription and chromatin

<p><div class="vf-tabs"><ul class="vf-tabs__list" data-vf-js-tabs="true"><li class="vf-tabs__item"><a class="vf-tabs__link" href="#vf-tabs__section-overview" data-vf-js-location-nearest-activation-target="">Overview</a></li><li class="vf-tabs__item"><a class="vf-tabs__link" href="#vf-tabs__section-sponsors" data-vf-js-location-nearest-activation-target="">Sponsors</a></li></ul><div class="vf-tabs-content" data-vf-js-tabs-content="true"><br /> <section class="vf-tabs__section" id="vf-tabs__section-overview"><h2 class="vf-u-sr-only">Overview</h2><br /> <p>This conference will take place at EMBL Heidelberg, with the option to attend virtually. </p></p> <p><p>Registration is not yet open for this event. If you are interested in receiving more information please register your interest. </p></p> <p><h2 class="wp-block-heading">Conference overview</h2></p> <p><p>The EMBL ‘Transcription and chromatin’ conference has a long-standing tradition in shaping the field of transcriptional regulation. The meeting brings together leading experts covering all aspects of transcription including cis-regulatory function, long range regulation, 3-dimensional looping, the basal transcriptional machinery, RNA polymerase regulation and function, nucleosome positioning, chromatin modifications, chromatin remodelling, and epigenetic inheritance of transcriptional silencing. The meeting contains many talks selected from the abstracts that are interspersed with invited speakers, discussing the latest breakthroughs in transcriptional regulation.</p></p> <p><p>The conference is designed to promote interactive discussions at both the talks and poster sessions. Given the excellent lineup of speakers and the meeting’s outstanding reputation, this is a must-attend for anyone interested in cutting-edge research in transcription.</p></p> <p><p></p></p> <p><h2 class="wp-block-heading"></h2></p> <p><h2 class="wp-block-heading">What past participants say about the conference</h2></p> <p><p>&#8220;<em>An &#8216;absolutely must attend&#8217; conference for scientists in gene expression regulation. The conference covers many topics besides transcription, epigenetics, and 3D genome and is a hub to network with other scientists developing cutting-edge techniques to study chromatin.</em>&#8221; &#8211; Chaitali Chakraborty, Umeå University, Sweden</p></p> <p><p>&#8220;<em>Fantastic dynamic meeting in an amazing setting of EMBL conference center. Plenty of discussion opportunities during poster sessions and unpublished findings presented at talks.Great balance of junior and senior faculty.</em>&#8221; &#8211; Ganna Panasyuk, Inserm-Institute Necker Enfants Malades, France</p></p> <p><p>&#8220;<em>Incredible lineup and fruitful scientific discussions. It was a genuine pleasure to be part of this great event and to share our recent work with such a knowledgeable and enthusiastic community. The diverse range of topics and the depth of the presentations made for an engaging experience, and the opportunity to network with other experts was invaluable. I look forward to applying the insights gained here to our ongoing research and future collaborations.</em>&#8221; &#8211; Mathias Boulanger, EMBL Heidelberg, Germany</p><br /> </section></p> <p><section class="vf-tabs__section" id="vf-tabs__section-sponsors"><h2>Sponsors</h2><br /> <p></p></p> <p><p><strong>Sponsorship opportunities</strong></p></p> <p><p>We offer a variety of event sponsoring possibilities, with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget.&nbsp;Discounts are available for companies sponsoring multiple events at EMBL Heidelberg.&nbsp;<a href="<a href="http://www.embl.org/events">View">http://www.embl.org/events">View</a> other conferences</a>, or contact&nbsp;<a href="<a href="mailto:sponsorship@embl.de">sponsorship@embl.org</a>&nbsp;for">mailto:sponsorship@embl.de">sponsorship@embl.org</a>&nbsp;for</a> further information on sponsoring possibilities.</p></p> <p><p>If you are interested in becoming a media partner of this event, please visit our<a href="<a href="https://www.embl.org/about/info/course-and-conference-office/sponsor-an-event/#vf-tabs__section-08208670-4ad4-45ca-a4ff-ac6edb6ffd0b&quot">https://www.embl.org/about/info/course-and-conference-office/sponsor-an…</a>; target="_blank" rel="noreferrer noopener">&nbsp;media partnerships webpage.</a></p></p> <p><div class="wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex"><p><a href="<a href="mailto:sponsorship@embl-em.de?subject=%20Request%20a%20Sponsorship%20Brochure&#038;body=Please%20kindly%20send%20me%20the%20sponsorship%20brochure%20for%20(please%20indicate%20the%20event%20your%20are%20interested%20in).&quot">mailto:sponsorship@embl-em.de?subject=%20Request%20a%20Sponsorship%20Br…</a>; class="vf-button vf-button--primary vf-button--pill">Request a sponsorship brochure</a></p></div></p> <p><div class="vf-box vf-box--normal vf-box-theme--quaternary | vf-u-margin__bottom--400"><br /> <h3 class="vf-box__heading"><br /> Warning </h3><br /> <p class="vf-box__text">EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials. One current scam campaign of which we are aware is conducted using the name ‘Judy Eastman’ (<a href="mailto:judy@gopcontact.a2hosted.com">judy@gopcontact.a2hosted.com</a>) and entails approaches to sponsors offering sponsorship opportunities on EMBL’s behalf. Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences, symposia and courses is handled by EMBL directly and is sent from an official EMBL account. EMBL does not work with any external providers on sponsorship acquisition.</p><br /> <p class="vf-box__text">Please also note that:</p><br /> <ul><br /> <li><span style="font-size: 12pt;">EMBL never provides attendee lists for purchase. Any offers of such are fraudulent.</span></li><br /> <li><span style="font-size: 12pt;">EMBL will never call or email you to ask for your credit card details or to request a payment.</span></li><br /> <li><span style="font-size: 12pt;">All payments are on invoice.</span></li><br /> </ul><br /> <p class="vf-box__text">Suspicious communications purportedly from, for or on behalf of EMBL should be reported to EMBL at the following email address <a href="mailto:sponsorship@embl.de">sponsorship@embl.de</a>.</p><br /> </div></section><br /> </div></div></p>

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